James M Phang Selected Research

Proline (L-Proline)

12/2021	Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis.
1/2020	Proline Metabolism in Tumor Growth and Metastatic Progression.
1/2019	Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses.
11/2015	Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides.
1/2015	Proline metabolism and cancer: emerging links to glutamine and collagen.
11/2012	Proline dehydrogenase (oxidase) in cancer.
9/2012	Proline dehydrogenase (oxidase), a mitochondrial tumor suppressor, and autophagy under the hypoxia microenvironment.
7/2012	Proline oxidase promotes tumor cell survival in hypoxic tumor microenvironments.
6/2012	Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.
1/2012	Proline metabolism and cancer.

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James M Phang Research Topics

Disease

22	Neoplasms (Cancer) 12/2021 - 04/2004
7	Carcinogenesis 11/2015 - 12/2002
5	Colorectal Neoplasms (Colorectal Cancer) 07/2009 - 04/2004
4	Hypoxia (Hypoxemia) 09/2012 - 09/2004
3	Prolidase Deficiency 03/2015 - 03/2008
2	Obesity 08/2010 - 09/2004
2	Breast Neoplasms (Breast Cancer) 03/2008 - 01/2002
2	Neoplasm Metastasis (Metastasis) 03/2008 - 12/2005
1	Blindness (Hysterical Blindness) 04/2015
1	Gyrate Atrophy 04/2015
1	Metabolic Bone Diseases (Osteopenia) 03/2015
1	Microcephaly 03/2015
1	Hypertelorism 03/2015
1	Genu Valgum 03/2015
1	Mouth Neoplasms (Oral Cancer) 01/2015
1	Hypertrophy 04/2011
1	Inflammation (Inflammations) 10/2008
1	Colonic Neoplasms (Colon Cancer) 01/2006
1	Genomic Instability 04/2005
1	Sarcoma (Soft Tissue Sarcoma) 09/2004
1	Lymphoma (Lymphomas) 09/2004
1	Urinary Bladder Neoplasms (Bladder Cancer) 09/2004
1	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 12/2002
1	Prostatic Neoplasms (Prostate Cancer) 01/2002

Drug/Important Bio-Agent (IBA)

14	Proline (L-Proline)FDA Link 12/2021 - 10/2008
10	Proline Oxidase (Proline Dehydrogenase)IBA 01/2019 - 08/2005
7	EnzymesIBA 01/2020 - 04/2005
7	Glucose (Dextrose)FDA LinkGeneric 11/2015 - 03/2008
5	CollagenIBA 01/2020 - 04/2005
5	Proteins (Proteins, Gene)FDA Link 01/2019 - 04/2005
4	proline dipeptidase (prolidase)IBA 03/2015 - 04/2005
4	PPAR gammaIBA 11/2012 - 01/2006
3	Glutamine (L-Glutamine)FDA Link 11/2015 - 06/2012
3	Oxidoreductases (Dehydrogenase)IBA 01/2015 - 09/2012
3	Adenosine Triphosphate (ATP)IBA 11/2012 - 07/2012
3	Transcription Factors (Transcription Factor)IBA 11/2012 - 09/2004
3	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2012 - 01/2007
2	Amino Acids FDA Link 11/2015 - 01/2015
2	Oxygen (Dioxygen)IBA 01/2015 - 11/2012
2	MicroRNAs (MicroRNA)IBA 11/2012 - 01/2012
2	AMP-Activated Protein KinasesIBA 09/2012 - 07/2012
2	LDL Lipoproteins (beta Lipoproteins)IBA 08/2010 - 03/2010
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2005 - 04/2004
2	NickelIBA 04/2005 - 09/2004
1	Membrane Transport Proteins (Biological Pump)IBA 01/2019
1	NucleotidesIBA 11/2015
1	pyridineIBA 11/2015
1	Transaminases (Aminotransferases)IBA 04/2015
1	OrnithineIBA 04/2015
1	Mutant Proteins (Protein, Mutant)IBA 03/2015
1	Protein Deglycase DJ-1IBA 01/2015
1	delta-1-pyrroline-5-carboxylateIBA 01/2015
1	Essential Amino AcidsIBA 03/2013
1	GlutaminaseIBA 06/2012
1	AntagomirsIBA 01/2012
1	IntegrinsIBA 04/2011
1	MorpholinosIBA 04/2011
1	ArsenicIBA 05/2010
1	Small Interfering RNA (siRNA)IBA 03/2010
1	oxidized low density lipoproteinIBA 03/2010
1	Beclin-1IBA 03/2010
1	LuciferasesIBA 03/2008
1	Metalloproteases (Metalloproteinases)IBA 03/2008
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2008
1	Matrix Metalloproteinases (MMPs)IBA 03/2008
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2008
1	LigandsIBA 01/2006
1	Troglitazone (Rezulin)FDA Link 01/2006
1	Tetracycline (Achromycin)FDA LinkGeneric 08/2005
1	CobaltIBA 09/2004
1	Insulin-Like PeptidesIBA 09/2004
1	LeptinIBA 09/2004
1	OligonucleotidesIBA 09/2004
1	Insulin-Like Growth Factor I (IGF-1)IBA 09/2004
1	AminesIBA 09/2004
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 04/2004
1	Proto-Oncogene Proteins c-etsIBA 04/2004
1	beta CateninIBA 12/2002
1	Acetylcysteine (Siran)FDA LinkGeneric 01/2002
1	Testosterone CongenersIBA 01/2002
1	AntioxidantsIBA 01/2002
1	MetriboloneIBA 01/2002
1	Dehydroepiandrosterone (DHEA)IBA 01/2002
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2002
1	FenretinideIBA 01/2002
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2002
1	Cyclophilins (Cyclophilin)IBA 01/2002
1	RNA (Ribonucleic Acid)IBA 01/2002
1	Cyclophilin AIBA 01/2002
1	RetinoidsIBA 01/2002
1	Prednisone (Sone)FDA LinkGeneric 01/2002

Therapy/Procedure

5	Therapeutics 01/2020 - 08/2009